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mitotane will lessen the level or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.Abemaciclib targets CDK4 and CDK6, proteins that aid regulate cell division. M